News & Events

MEDIA RELEASE - NPS MedicineWise and NCIRS announce national partnership

Sep 2017 - News

NPS MW ID RGBNPS MedicineWise has partnered with the National Centre for Immunisation Research and Surveillance (NCIRS) to deliver a landmark, nationally coordinated immunisation support program for Primary Health Networks (PHNs) across Australia.

The program, entitled the Primary Health Networks Immunisation Support Program, will be co-designed with PHNs to better support and coordinate immunisation providers and services in their regions. The aim is to ensure PHN efforts across the country deliver on National Immunisation Program goals and are as consistent as possible, while addressing specific challenges in their local areas.

Immunisation providers, including GPs, nurses, community health clinics, Aboriginal Medical Services, local councils and pharmacies will benefit from the new PHN immunisation programs which will be consistent with the Australian Immunisation Handbook guidance, but adapted to be more targeted to specific community and patient requirements.

NPS MedicineWise CEO, Lynn Weekes, says: “We are pleased to partner with NCIRS on such a nationally significant and essential undertaking to enhance the effectiveness of immunisation services throughout the country.

“Supporting the invaluable work of PHNs by ensuring they are well-equipped with consistent and tailored immunisation information for the health professionals working in their local communities, is our priority in the development of this new program.”

The program is in early stages of development during which NCIRS and NPS MedicineWise will undertake a systematic consultation process with PHNs and key stakeholders around the country to identify and respond to their particular challenges and requirements in the immunisation space.

NCIRS Deputy Director, Associate Professor Kristine Macartney, says, “The input and local insights we receive from PHNs will be crucial to informing the program’s development.

“This and the combined expertise of NCIRS and NPS MedicineWise put us in a strong position to work to ensure that future PHN immunisation programs are consistent and that they effectively deliver messages that are relevant to local communities and immunisation providers across Australia. This should enable us to protect more people from disease through effective delivery of immunisation. ”

Media enquiries: Eve Hanks (02) 8217 9667, 0419 618 365 or or Jonathon Abbott (02) 8217 9650 or

About NPS MedicineWise: Independent, evidence-based and not-for-profit, NPS MedicineWise enables better decisions about medicines and medical tests. We receive funding from the Australian Government Department of Health.

About NCIRS: The National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (NCIRS) is the leading organisation in Australia working in research to support evidence-based policy development for evaluation of the National Immunisation Program, and surveillance of vaccine preventable diseases, vaccine coverage and vaccine safety. This work is funded through agreements with the Australian Government Department of Health. For more information on NCIRS visit

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Flu is a tragic illness. How can we get more people to vaccinate?

Sep 2017 - News

File 20170921 16560 1nqeo0y Most people don’t take flu seriously enough. from

Julie Leask, University of Sydney and Samantha Carlson, University of Sydney and Research Officer NCIRS

Flu (influenza) has traditionally been the underdog of vaccine-preventable diseases. People tend not to worry about the flu too much, and there are various myths about its prevention and the vaccine. It’s true most people experience flu as a mild disease, but many don’t recognise it can be more severe.

Each year flu is estimated to kill at least 3,000 Australians aged over 50 years alone. It took more children’s lives than any other vaccine preventable disease in Australia between 2005-2014, and is the most common vaccine preventable disease that sends Australian children to hospital.

The tragic death of eight-year-old Rosie Andersen from flu this week has followed the recent outbreaks in aged care facilities and subsequent deaths of residents in South Australia, Tasmania and Victoria. A 30-year-old father died earlier this month due to complications from the flu, and now Sarah Hawthorn, who was infected late in her pregnancy, remains in a coma, unaware her baby was safely delivered six weeks ago.

This year’s flu season has been a bad one. And it’s not over yet.

Australian studies have shown the flu vaccine can usually reduce the risk of flu in those who are vaccinated by 40-50%, and by 50-60% for children. Early indications are showing the effectiveness of this year’s flu vaccine may be lower.

Experts are calling for a better vaccine, which is needed. But even a more effective vaccine won’t address all the barriers to uptake.

Read more: Flu vaccine won’t definitely stop you from getting the flu, but it’s more important than you think

Who’s most at-risk?

Annual flu vaccination is recommended for any person six months of age or older who wishes to reduce the likelihood of becoming ill with flu. It’s free for certain groups at higher risk of the severe effects of the disease including:

• people over 65 (80% of whom are vaccinated)

• Aboriginal and Torres Strait Islander people from six months to five years (12% of whom are vaccinated)

• Aboriginal and Torres Strait Islander people over 15 (34% of whom are vaccinated)

• pregnant women (45% of whom are vaccinated)

• people aged six months and over with medical conditions such as severe asthma, lung or heart disease, low immunity or diabetes (58% of these adults are vaccinated, and 27% of these children).

Why don’t they vaccinate?

Researchers have looked at why many people in these groups don’t have their yearly flu vaccine. A common theme emerges - health professionals are not recommending it enough, people aren’t aware they need it, they’re not sufficiently motivated, or they don’t have easy access.

These themes come out in studies with parents of young children, pregnant women, Aboriginal and Torres Strait Islander children, adults with other disease, and people over 65.

The flu vaccine isn’t free for all kids. from

Our research is now looking at the children who end up in hospital with severe flu. We’re trying to better understand the barriers to flu vaccination, along with vaccine efficacy issues.

We’ve heard that not only are health care workers not recommending it enough, some doctors are even recommending against it, as they don’t believe the child is at risk. This is even though over half of children hospitalised from the flu are those without medical risk factors. Other times it’s simple awareness - parents didn’t know their child can receive a flu vaccine if they’re over the age of six months.

Busy lives can mean making time to go to the clinic for a vaccine falls down the list of priorities. A four-year-old in our study was hospitalised only three days before a visit to the clinic had been booked.

Some of the children in our study were not theoretically at high risk of flu and so not in the group where the vaccine is free. This was a major barrier, as it has been in other studies in children and adults. Parents report to us that their child is up-to-date with their scheduled vaccines, but annual flu vaccination is not being ticked off as it’s not on the schedule.

The challenge with flu vaccine is it’s given yearly. In the UK it’s recommended and funded for all children of primary school age using a school-based delivery program and currently between 53-58% of children have it. When this many children are vaccinated there can be indirect protection of others who are not vaccinated because the virus is not able to spread from person to person as easily.

Read more: I’ve always wondered: why is the flu virus so much worse than the common cold virus?

Misconceptions about the flu vaccine

Misconceptions about flu vaccine are also a barrier: that it causes flu, that it’s not effective, that it’s not needed. People might say they never get the flu, not realising symptoms can be mild or not noticed and they can pass it on to the vulnerable. Others reported their belief was that the flu was not a serious disease. Some believed contracting flu “naturally” was likely to provide greater immunity.

Some parents also have concerns about the safety of the flu vaccine. Australians were spooked by a 2010 incident when there was a temporary suspension of flu vaccine for children under five after reports of an increase in the rate of convulsions in children.

The one vaccine found to be the cause (BioCSL/Sequiris Fluvax™) is no longer approved for use in children younger than five, but there are other seasonal flu vaccines children can have. But public and professional confidence is yet to fully recover, despite having reassuring safety data.

People may say they never get the flu so they don’t need the vaccine, but you can pass on the virus without knowing you have it. from

Western Australia has had a free child vaccine program for years which was achieving relatively good coverage, but this dramatically declined after 2010, and coverage languishes at around 15% today. In other words, mud sticks.

How to improve uptake

To improve uptake we first need timely and accurate coverage figures. We now have the capacity to get coverage estimates from the expanded Australian Immunisation Register but these are not yet available.

The vaccine needs to be recommended more often, available more readily, free and recommended as part of the schedule, and myths addressed more effectively.

We need to motivate and support health care workers to implement the recommendations, such as with automated reminders, incentives and performance indicators. Systems need to ensure people can get the vaccine easily - from the GP or other health clinic, the specialist clinic, the antenatal care clinic, or from an Aboriginal or Torres Strait Islander health worker.

The ConversationPromoting flu vaccine to everyone is important, as is providing ease of access, awareness and opportunity. Although the flu vaccine isn’t perfect, it’s far better than no protection at all.

Julie Leask, Associate Professor, University of Sydney and Samantha Carlson, Research Officer for the National Centre for Immunisation Research and Surveillance, University of Sydney

This article was originally published on The Conversation. Read the original article.

Updated resources for meningococcal vaccines

Sep 2017 - News

NCIRS has updated its meningococcal fact sheet and developed a new FAQ fact sheet for use by providers. The FAQ in particular provides answers to questions on the use of MenACWY vaccines. Please see links below:

Meningococcal vaccines for Australians [PDF – 711kB

Meningococcal vaccines – frequently asked questions [PDF – 590kB]

Updated resources for zoster vacines

Aug 2017 - News

The following NCIRS factsheets have recently been updated:

Zoster vaccine for Australian adults [PDF – 489kB]

Zoster vaccine – frequently asked questions [PDF – 389kB]

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Updated - Australian Immunisation Handbook 10th Edition

Aug 2017 - News

The Australian Immunisation Handbook 10th Edition has been updated and can be viewed on the Immunise Australia website

The following chapters and appendices have been updated:

  • Updates page
  • 2.1
  • 3.3
  • 4.2
  • 4.3
  • 4.4
  • 4.9
  • 4.11
  • 4.12
  • 4.13
  • 4.14
  • 4.16
  • 4.17
  • 4.18
  • 4.19
  • 4.20
  • 4.21
  • 4.22
  • 4.23
  • 4.24
  • Appendix 3
  • Appendix 4
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Registrations are now open for the next NCIRS Seminar on Wednesday 27th September 11am-12pm

Aug 2017 - Events

NCIRS Seminar Series 2017 #6 - Wednesday 27th September 11am-12pm
Addressing vaccine hesitancy and refusal

A/Prof Julie Leask – University of Sydney

Time: Wednesday 23rd August 11am-12pm
Location: Seminar Room 1 and 2, CMRI Building, 214 Hawkesbury Road, Westmead, NSW

Register here (for catering please)

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No, combination vaccines don't overwhelm kids' immune systems

Aug 2017 - News

Kristine Macartney, University of Sydney, and Deputy Director NCIRS
Originally published on The Conversation.

Parents are concerned combination vaccines, which protect against several diseases at once, can be too much for a young immune system to cope with.

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No parent likes seeing their child have injections. Yet, around 93% of parents across Australia protect their children against 15 serious diseases by giving them all the recommended vaccines on the National Immunisation Program Schedule. This success is due in part to the value of combination vaccines, which protect against two or more diseases in one go.

Combination vaccines mean kids need fewer injections overall. By adding several antigens (the part of the germ that stimulates the immune system) together in one vaccine, we can protect kids against up to six diseases in a few shots. These shots are typically given in a series of two or three injections over time.

Our new study released today in JAMA Pediatrics, backs the safety of a four-in-one combination vaccine – designed to protect against measles, mumps, rubella and varicella (chickenpox) and known as the MMRV vaccine. We also show its added benefits in protecting kids by the time they reach pre-school.

Read more: Six myths about vaccination – and why they’re wrong

Making a combination vaccine typically involves decades of research to ensure the precise balance of “active” components is included, the immune response to each component is effective, and even the slightest change in a vaccine doesn’t change its safety profile.

This is stringently regulated across the world, by groups such as the Therapeutic Goods Administration in Australia and Food and Drug Administration in the USA, before a vaccine is even trialled in humans, or indeed ultimately licensed for use.

This video, from the Children’s Hospital of Philadelphia, outlines the steps taken to develop, and evidence behind, combination vaccines.

Once these combination vaccines are used, their safety (as well as the safety of other vaccines) is also actively monitored. One new way we do this in Australia is by monitoring any side-effects in real time. Parents respond to an SMS survey about their child’s recent vaccination, the results of which are collated and posted online.

Too much to handle?

However, some parents question if giving an injection that protects against multiple diseases will overwhelm the immune system or be too much to handle. The answer is “no” for many reasons.

A review into parental concerns about combination vaccinations confirms the moment babies enter the world they are covered in millions of foreign germs. The infant immune system is no longer considered “immature” but is finely tuned to respond to the incredible number of viruses, bacteria and other things it meets early in life. Vaccines contain just a few antigens compared to what babies meet every day.

The researchers estimate that even if 11 vaccines were given to infants at one time, only about 0.1% of the immune system would be “used up”.

Read more: Explainer: how does the immune system work?

Rather than weaken the immune system, or putting it under strain, vaccines train the infant immune system to respond, without causing the terrible consequences of the disease itself. Combination vaccines do the same.

The design of vaccines has been increasingly tailored to leverage this unique biology, including the development of new combination vaccines.

Read more: Vaccine program changes protect kids, but with fewer ouches

For instance, in 2013, two new combination vaccines – the MMRV vaccine and a combination vaccine against the Haemophilus influenzae type b and meningococcus type c bacteria (Hib-MenC) – were added to Australia’s immunisation schedule, reducing the number of injections babies needed.

Tackling four diseases at once, and measles

Our new study evaluated the impact of one these – the MMRV vaccine – since it was added to the schedule.

Before the MMRV vaccine was introduced, kids were protected against varicella (or chickenpox) with a separate vaccine. And they received their second dose of measles-mumps-rubella (MMR) vaccine at age four years, quite a big gap after their first-birthday dose of MMR.

By introducing this combination MMRV vaccine earlier (at 18 months), our study showed the second dose of vaccine against measles provided early comprehensive protection against this deadly disease.

While the first vaccine dose (given at 12 months) only gives a full immune response in about 90% of children, giving a second dose boosts immunity to more than 95% and also helps to provide longer lasting protection.

The MMRV combination vaccine means more children are protected against chickenpox, mumps and rubella (german measles) before entering pre-school.

Our study showed not only that the percentage of children fully protected against all four diseases is now greater compared with when MMR was separated from the varicella vaccine, it is also occurring at a much earlier age.

“On time” vaccination (within 30 days of the recommended age) has now improved by 13.5% (from 58.9% to 72.4% of children). This means many more children are protected against measles, chickenpox, mumps and rubella (German measles) before entering pre-school.

Tackling four diseases at once, and safety

Another important part of our evaluation was to ensure that introducing this vaccine was safe. If the combination MMRV vaccine is given as the very first dose of measles-containing vaccine in very young children, it causes more cases of fever and a small increase in febrile seizures (a common, usually benign, but frightening convulsion in children) compared with giving the vaccines separately.

Our study examined if using the MMRV shot in the Australian program as the second dose would be linked to an increase in febrile seizures. When we examined all children who came to paediatric hospitals across the country with a febrile convulsion, then looked at what vaccines they had received, we found no increase in febrile seizures associated with this second dose given at 18 months.

So introducing this combination vaccine in 2013, which has taken decades to develop, has:

  • reduced the number of injections children need
  • helped improve the total number of children vaccinated on time, and
  • has been safe.

In a nutshell

Combination vaccines not only mean fewer visits to the doctor or nurse for injections, they can have other benefits, as well as being safe.

Our study highlights how much information is considered before making any change to the immunisation schedule to introduce combination vaccines, and importantly, how carefully changes to the schedule are monitored and evaluated.

The ConversationWhile combination vaccines might introduce extra antigens to a child’s immune system in one go, they are a tiny, tiny proportion of what children meet as they grow. Being vaccinated trains a child’s immune system to withstand some of the biggest and baddest germs they will encounter.

Kristine Macartney, Associate Professor, Discipline of Paediatrics and Child Health, University of Sydney

This article was originally published on The Conversation. Read the original article.

Media Release: 4-in-1 Combination Vaccine Improves National Vaccination Uptake

Aug 2017 - News

Nationwide on-time protection against measles and other diseases has increased by more than 13 per cent since the introduction of the 4-in-1 measles-mumps-rubella-varicella (MMRV) vaccine for toddlers in 2013, a recent study has revealed.

According to the study, which was carried out by the Paediatric Active Enhanced Disease Surveillance (PAEDS) in conjunction with The National Centre for Immunisation Research and Surveillance (NCIRS), the uptake of on-time measles-containing vaccinations has increased nationally by 13.5% over the last four years, when the MMRV vaccine was first introduced into the National Immunisation Program (NIP).

Prior to July 2013, MMRV vaccines were not used in Australia. Two doses of measles-mumps-rubella (MMR) vaccines were scheduled on the NIP at ages 12-months and 4 years, similar to the US and UK schedules. In an effort to increase the population-level vaccine coverage as well as protection for each individual child, the scheduled age for the second MMR dose was brought forward to 18 months (after the first dose of MMR at 12-months) and replaced with MMRV vaccine.

Deputy Director of Government Programs at the NCIRS and paediatric infectious disease consultant Associate Professor, Kristine Macartney says, “Since implementing the compressed immunisation schedule at ages 12 and 18 months, there has been a 13.5% nationwide improvement in coverage and on-time vaccinations against all four diseases. We have also demonstrated that more children were fully protected against measles at an earlier age.”

“From a family’s perspective, a 4-in-1 vaccine is much more convenient and helps with vaccine acceptance, coverage and ultimately, disease control. Moreover, use of MMRV vaccine as dose 2 of measles containing vaccine (MCV) at the age of 18 months is proven to be a safe way to prevent these diseases. In overseas studies, use of this as dose 1 gave rise to more fever and febrile seizures than had been seen before. However, we have proven that using it under the NIP as dose 2 doesn’t cause seizures,” she added.

Australia was one of the first 4 countries in the World Health Organisation Western Pacific Region to reach measles elimination status, officially declared in March 2014(1). Global efforts to control measles rely on achieving and maintaining high 2-dose vaccine coverage of more than 95% at a country and district level(2). Introducing this 4-in-1 combination vaccine at the younger age of 18 months should help us to maintain that elimination status.

Read the full article here

(1) Gidding HF, Martin NV, Stambos V, et al. Verification of measles elimination in Australia: application of World Health Organisation regional guidelines. J Epidemiol Glob Health. 2016;6(3):197-209
(2) Bester JC. Measles and measles vaccination: a review. JAMA Pediatr. 2016;170(12):1209-1215

Media contact: Sheri Locmayon
Public Relations Department
The Children's Hospital at Westmead
P: (02) 9845 3364

Influenza Vaccine Safety Surveillance Data Update

Jul 2017 - News

In 2017, four age-specific quadrivalent influenza vaccines are available under the National Immunisation Program (NIP). The current safety profile of the 2017 vaccines is reassuring and consistent with expectations. As at 30th July 2017 almost 70,000 people have participated in active influenza vaccine safety surveillance via SMS/email representing a 72% participation rate. Real-time, patient reported data on the safety of Zoster vaccine and Pertussis booster vaccines in children is also available.

View the current AusVaxSafety surveillance data

July 2017 - Newsletter

Jul 2017 - Newsletters

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